The three interventions reduced hospital survival compared with control (OR : 0.65, 0.56, and 0.36 ), yielding high probabilities of harm (98.5% and 99.4% and 99.8%, respectively).Īmong critically ill patients with COVID-19, lopinavir-ritonavir, hydroxychloroquine, or combination therapy worsened outcomes compared to no antiviral therapy.Īdaptive platform trial COVID-19 Hydroxychloroquine Intensive care Lopinavir-ritonavir Pandemic Pneumonia. The three interventions decreased organ support-free days compared to control (OR : 0.73, 0.57 0.41 ), yielding posterior probabilities that reached the threshold futility (≥ 99.0%), and high probabilities of harm (98.0%, 99.9% and > 99.9%, respectively). The median organ support-free days among patients in lopinavir-ritonavir, hydroxychloroquine, and combination therapy groups was 4 (- 1 to 15), 0 (- 1 to 9) and-1 (- 1 to 7), respectively, compared to 6 (- 1 to 16) in the control group with in-hospital mortality of 88/249 (35%), 17/49 (35%), 13/26 (50%), respectively, compared to 106/353 (30%) in the control group. We randomized 694 patients to receive lopinavir-ritonavir (n = 255), hydroxychloroquine (n = 50), combination therapy (n = 27) or control (n = 362). Analyses used a Bayesian cumulative logistic model and expressed treatment effects as an adjusted odds ratio (OR) where an OR > 1 is favorable. The primary endpoint was an ordinal scale of organ support-free days.
Please do not hesitate to contact us if you have any questions about our services or your treatment.To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19).Ĭritically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). We hope you will find the site a useful reference.
Alex p. nguyen oncology consultants pa professional#
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